The Science of “Reconstitution”
The skin is the largest organ and has the highest repository of stem cells in the body. In order for the skin to function properly, skin cells must continuously replace themselves. These replacement skin cells arise from stem cells in the dermis and epidermis. The number of stem cells within the skin remains relatively constant over time. However, with aging, stem cell divisions occur less frequently. This leads to lower than normal numbers of fibroblasts to make collagen and elastic tissues and to lower numbers of keratinocytes to make smooth, thicker skin. Stem cells can remain dormant, divide to form new stem cells, or differentiate into new skin cells. The decision to remain dormant, divide or differentiate is a critical one and is determined by signal pathways in the body that funnel into a common signaling pathway called “Wnt” (pronounced “wint”). A central “hub” protein for communication within the Wnt signaling pathway is called beta-catenin (β-catenin). Optimal Wnt signaling can help stem cells regain activities leading to a more healthy and youthful appearing skin.
Our proprietary molecule, Asymmtate™, has been formulated into the Renewnt™ (pronounced “Re-new-int”) brand of topical skin care products. Asymmtate is a selective modulator of the Wnt signaling pathway that encourages optimal signaling to stimulate skin stem cells to replenish themselves, keratinocytes, fibroblasts and other dermal cells, which produce collagen, elastic tissue, matrix and other substances to foster a more healthy, rejuvenated appearing skin.